Evaluation Screen Printed Carbon Electrode Modified With Poly (O-phenylenediamine) for Etodolac drug Detection

الملخص

A modified carbon electrode based on molecularly imprinted poly O-phenylenediamine was developed for the determination of etodolac. The modified electrode was prepared by incorporation of the template molecule etodolac during the electropolymerization of O-phenylene diamine on screen printed carbon electrode using cyclic voltammetry. The performance of the molecularly imprinted (MIP) and non-imprinted (NIP) electrodes were assessed by cyclic voltammetry. Differential pulse voltammetry, the influences of pH, monomer and template concentrations, electropolymerization cycles were optimized. For analytical objective, a well resolved voltammetric peak was obtained in 0.2 M phosphate buffer at pH 4.0 for differential pulse voltammetry. Linear responses in the range of 10.0 to 50.0 µM with detection limits of 5.0 µM were obtained for differential pulse voltammetry. The chemical sensor was applied successfully for the determination of etodolac in serum.